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KMID : 0363320130340010001
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Journal of Korean Oriental Internal Medicine
2013 Volume.34 No. 1 p.1 ~ p.13
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Effects of Jowiseungcheung-tang Extract on the Lipid Metabolism, Anti-oxidation and Inflammatory Reflex High Fat Diet Obese Rats
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Oh Sung-Won
Kim Byoung-Woo
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Abstract
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Objectives : The purpose of this study was to investigate the effects of Jowiseungcheung-tang (JWSCT) extract on the
lipid metabolism, anti-oxidation and inflammatory reflex.
Methods : Male Sprague-Dawley rats were fed a high fat diet for 8 weeks and were randomly divided into 4 groups (10
mice in each group): control group, 100 mg/kg JWSCT group, 200 mg/kg JWSCT group, 300 mg/kg JWSCT group. The
control group was administered 100 mg/kg of water, but the other three groups were administered 100, 200, 300 mg/kg JWSCT extract for 4 weeks. After 4 weeks, we measured lipid level, thiobarbituric acid reactive substance (TBARS), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and cytokines in plasma and liver. The gene expression level and the ratio of apo-B and apo-E were then investigated by way of reverse transcription -polymerase chain reaction (RT-PCR).
Results : In the JWSCT group, compared with the control, free fatty acid, triglyceride, total cholesterol, LDL-cholesterol,
TBARS, IL-1β, IL-6 and TNF-α decreased significantly in plasma and liver. However HDL-cholesterol, IL-10, GSH-Px, SOD
and CAT increased. In the JWSCT group, compared with the control, the gene expression level and the ratio of apo-A and
apo-E decreased significantly in the RT-PCR analysis.
Conclusions : The extract of JWSCT has anti-obesity, anti-inflammatory and anti-oxidant effects.
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KEYWORD
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Jowiseungcheung-tang (Diaoweish?ngq?ng-t?ng), lipid metabolism, anti-oxidation, inflammatory, anti-obesity
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